miRNA调控哺乳动物卵泡发育和卵母细胞成熟的研究进展

doi:10.11843/j.issn.0366-6964.2019.11.001

Abstract

Abstract: The regulation of female mammalian follicular development and oocyte maturation involves the spatiotemporal regulation of those genes that play key roles in reproduction. miRNAs, as a class of small non-coding RNAs, regulate the expression of most of these genes. Over the last decade, a large number of miRNAs involved in mammalian follicular development and oocyte growth were found through high-throughput sequencing, knockout of key genes involved in miRNA generation, and functional inhibition or overexpression of miRNAs. The function of these miRNAs in mammalian follicular development and oocyte maturation were ultimately determined by studying the interaction with their target genes. The present review focuses on the expression and potential function of major miRNAs during follicular development and oocyte maturation in reproductive cells or extracellular. These results can provide a reference for further exploring the regulation mechanism of mammalian reproduction.

CLC Number:

S814.1

HE Xiaoyun, LIU Qiuyue, CHU Mingxing. Advances in miRNA Regulating Mammalian Follicular Development and Oocyte Maturation[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(11): 2175-2185.

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Advances in miRNA Regulating Mammalian Follicular Development and Oocyte Maturation

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